Journal
NANOMATERIALS
Volume 7, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nano7100321
Keywords
MIL-125-NH2; metal-organic frameworks; nanoparticles; colloidal stability; drug delivery; pralidoxime
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Funding
- CNRS
- Universite de Versailles, IMDEA Energy Institute
- EU [ERC-2007-209241-BioMOFs ERC]
- Spanish Ramon y Cajal Programme [2014-16823]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme under REA [291803]
- Dutch Ministry of Defense (CBRN) [V1408]
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The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 degrees C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and the release of drugs. The nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or pralidoxime) was effectively encapsulated into the pores of MIL-125-NH2 as a result of the interactions between 2-PAM and the pore walls being mediated by pi-stacking and hydrogen bonds, as deduced from infrared spectroscopy and Monte Carlo simulation studies. Finally, colloidal solutions of MIL-125-NH2 nanoparticles exhibited remarkable stability in different organic media, aqueous solutions at different pH and under relevant physiological conditions over time (24 h). 2-PAM was rapidly released from the pores of MIL-125-NH2 in vitro.
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