Journal
NANOMATERIALS
Volume 7, Issue 2, Pages -Publisher
MDPI AG
DOI: 10.3390/nano7020035
Keywords
yttria; nanoprobes; optical imaging; magnetic resonance imaging; cytotoxicity; T-1-weighted contrast agent
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2016R1A2B4007611, 2014R1A2A1A11051146]
- Basic Science Research Program through the NRF of Korea - Ministry of Education [2016R1D1A1B03931076]
- National Research Foundation of Korea [2016R1A2B4007611, 2016R1D1A1B03931076, 2014R1A2A1A11051146] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T-1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging.
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