4.7 Article

Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs

Journal

NANOMATERIALS
Volume 7, Issue 7, Pages -

Publisher

MDPI AG
DOI: 10.3390/nano7070155

Keywords

biodegradable material; porous membrane; drug delivery; hybrid material

Funding

  1. Generalitat de Catalunya [2014-SGR-1015, 2014-SGR-524]
  2. Fondo Europeo de Desarrollo Regional, FEDER [MAT2014-57960-C3-1-R]
  3. Spanish Ministerio de Economia y Competitividad (MINECO) [MAT2014-57960-C3-3-R]
  4. MINECO [RYC-2012-10839, IJCI-2015-27030]

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Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms.

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