Journal
NANOMATERIALS
Volume 8, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/nano8010003
Keywords
asymmetrical discontinuous field function; blood-brain barrier (BBB); magnetic drug delivery; magnetic nanoparticles; aggregation
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Funding
- National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2012-0009524, 2017R1A2B4011704]
- National Research Foundation of Korea [2017R1A2B4011704, 2012-0009524] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The blood-brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel scheme with an aggregation model for a feed-forward magnetic actuation design. A simulation platform for aggregated particle delivery is developed and an actuation scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic actuation. The experimental results with a Y-shaped channel indicated the success of the proposed scheme in steering and disaggregation. The delivery performance of the developed scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed scheme enhanced the transport and uptake of MNPs across the BBB in mice. The scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic actuation scheme.
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