Journal
NANOMATERIALS
Volume 7, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nano7110351
Keywords
metal-organic framework; nanoparticles; drug delivery; combination therapy
Categories
Funding
- Center for Nanoscience (CeNS)
- Deutsche Forschungsgemeinschaft (DFG) [WU 622/4-1, SFB1032(B11)]
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One of the main problems for effective treatment of cancer is resistances, which often require combination therapyfor effective treatment. While there are already some potential drug carrierse.g., liposomes, available for treatmentthe effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.
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