Soluble CD40 ligand derived from serum is not correlated with early MS

Background: Soluble CD40 ligand (sCD154) is a proinflammatory and prothrombotic ligand belonging to the tumor necrosis factor family. It has been shown by a variety of studies that sCD154 is elevated in the serum of patients afflicted with system autoimmune diseases. The aim of our study was to address whether sCD154 is increased in disease affected by Multiple Sclerosis (MS). Methods: Twenty MS patients who have been newly diagnosed as clinically definite multiple sclerosis (CDMS) along with twenty age and sex matched healthy individuals were recruited for this study. Serum cCD154 was measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: The results showed no statistically meaningful difference between newly diagnosed MS patients (3.07 ng/ul +/- 0.66) and control group (2.95 ng/ul +/- 0.79; p=0.62) Conclusion: Regarding our study, it seems that soluble CD40 ligand derived from serum is not correlated with early stage of MS disease.