Journal
JOURNAL OF HUNTINGTONS DISEASE
Volume 5, Issue 4, Pages 333-342Publisher
IOS PRESS
DOI: 10.3233/JHD-160200
Keywords
Huntington's disease; cholinergic; acetylcholine; choline acetyltransferase; cholinergic receptors; cholinergic drugs
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In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington's disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington's disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.
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