Journal
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume 32, Issue 1, Pages 42-61Publisher
KOREAN ASSOC INTERNAL MEDICINE
DOI: 10.3904/kjim.2016.198
Keywords
Clustered regularly interspaced short palindromic repeats-Cas9; Clustered regularly interspaced short palindromic repeats; Gene editing; Induced pluripotent stem cells; Genetic therapy
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2013R1A1A1076125]
- National Research Foundation of Korea [2013R1A1A1076125] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology-and particularly clustered regularly interspaced short palindromic repeats (CRISPR)-will allow us to improve our understanding of genomic variation in disease processes via cellular and animal models. Here, we highlight the progress made in correcting gene mutations in monogenic hereditary disorders and discuss various CRISPR-associated applications, such as cancer research, synthetic biology, and gene therapy using induced pluripotent stem cells. The challenges, ethical issues, and future prospects of CRISPR-based systems for human research are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available