Journal
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Volume -, Issue 127, Pages -Publisher
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/55968
Keywords
Engineering; Issue 127; Super-resolution far-field imaging; diffraction limit; hyperbolic metamaterials; hyperlens; real-time imaging; novel microscope; nanofabrication
Categories
Funding
- Young Investigator program [NRF-2015R1C1A1A02036464]
- Engineering Research Center program [NRF-2015R1A5A1037668]
- Global Frontier program [CAMM-2014M3A6B3063708]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning (MSIP) of Korean government [NRF-2017H1A2A1043204, NRF-2017H1A2A1043322, NRF-2016H1A2A1906519]
- National Research Foundation of Korea [2016H1A2A1906519, 2015R1C1A1A02036464, 2015R1A5A1037668] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The use of super-resolution imaging to overcome the diffraction limit of conventional microscopy has attracted the interest of researchers in biology and nanotechnology. Although near-field scanning microscopy and superlenses have improved the resolution in the near-field region, far-field imaging in real-time remains a significant challenge. Recently, the hyperlens, which magnifies and converts evanescent waves into propagating waves, has emerged as a novel approach to far-field imaging. Here, we report the fabrication of a spherical hyperlens composed of alternating silver (Ag) and titanium oxide (TiO2) thin layers. Unlike a conventional cylindrical hyperlens, the spherical hyperlens allows for two-dimensional magnification. Thus, incorporation into conventional microscopy is straightforward. A new optical system integrated with the hyperlens is proposed, allowing for a sub-wavelength image to be obtained in the far-field region in real time. In this study, the fabrication and imaging setup methods are explained in detail. This work also describes the accessibility and possibility of the hyperlens, as well as practical applications of real-time imaging in living cells, which can lead to a revolution in biology and nanotechnology.
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