Journal
JOURNAL OF THORACIC DISEASE
Volume 9, Issue 7, Pages 1919-1929Publisher
AME PUBL CO
DOI: 10.21037/jtd.2017.06.15
Keywords
Short-term; high-intensity; preoperative rehabilitation (PR); lung cancer (LC)
Categories
Funding
- Foundation of Science and Technology support plan, Department of Sichuan Province, China [2014SZ0148, 2015SZ0158]
Ask authors/readers for more resources
Background: The feasibility and practicality of preoperative rehabilitation (PR) programs remains quite controversial in the treatment of lung cancer (LC). This study explored whether a short-term high-intensity rehabilitation program could improve postoperative outcomes compared to those achieved with conventional inspiratory muscle training (IMT). Methods: A three-armed randomized controlled trial comparing the two training modalities and routine care was conducted in surgical LC patients. Patient groups received one of three treatment regimens: (I) high-intensity pulmonary rehabilitation (PR) that combined IMT with conventional resistance training (CRT) (combined PR group); (II) conventional PR (single IMT group); or (III) routine preoperative preparation (control group). The primary endpoint was a change in the occurrence of post-operative pulmonary complications (PPCs) that occurred within 30 days after surgery, while secondary endpoints included changes in length of hospital stay, quality of life (QoL) scores, 6-min walk distance (6-MWD) and peak expiratory flow (PEF). Results: A total of 90 enrolled patients were randomized into three groups with a computer-based 1:1:1 ratio. The intention-to-treat analysis of the study revealed that, compared with the Control Group, the Combined PR Group had a significant increase in (Delta)6-MWD (by 32.67 m, P = 0.002), (PEF)-P-Delta (by 14.3 L/min, P = 0.001), (Delta)global scores (by 3.7, P = 0.035); and a reduced (Delta)average total hospital stay (by 3.2 d, P = 0.001) and Delta postoperative stay (by 3.6 d, P = 0.001). With regard to PPC rate, the Combined PR Group had a somewhat lower PPC severity (grade II-V) compared to the Control Group. Conclusions: This hospital-based short-term program of PR combining high-intensity IMT with CRT was significantly superior to the conventional IMT program, indicating that this approach would be a feasible strategy for treating LC patients, especially those waiting operations with surgery-related risk factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available