Journal
MICROBIOLOGY SPECTRUM
Volume 4, Issue 6, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/microbiolspec.MCHD-0050-2016
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Funding
- Howard Hughes Medical Institute
- National Institutes of Health National Institute of Allergy and Infectious Diseases [R01 AI068041-09, R01 AI108834-01A1]
- Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease award [1007845]
- Canadian Institutes of Health Research Postdoctoral Fellowship
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Specialized adaptations for killing microbes are synonymous with phagocytic cells including macrophages, monocytes, inflammatory neutrophils, and eosinophils. Recent genome sequencing of extant species, however, reveals that analogous antimicrobial machineries exist in certain non-immune cells and also within species that ostensibly lack a well-defined immune system. Here we probe the evolutionary record for clues about the ancient and diverse phylogenetic origins of macrophage killing mechanisms and how some of their properties are shared with cells outside the traditional bounds of immunity in higher vertebrates such as mammals.
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