Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms17121997
Keywords
p53; I kappa B-alpha; tumor suppressors; functional inactivation
Funding
- Italian Ministero della Salute, Giovani Ricercatori-Ricerca Finalizzata [GR-2011-02351167]
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TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and interactions with other proteins. Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and I kappa B-alpha, he NFKBIA gene product.
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