Journal
GENES
Volume 8, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/genes8030092
Keywords
DNA replication; DNA replication stress; checkpoint response; Chk1; E2F-dependent transcription; E2F6; oncogene-induced replication stress
Categories
Funding
- Robertus A.M. de Bruin's Cancer Research UK Programme Foundation Award
- MRC [MC_U12266B]
- Cancer Research UK [20147] Funding Source: researchfish
- Medical Research Council [1223181, MC_CF12266, MC_U12266B] Funding Source: researchfish
Ask authors/readers for more resources
During DNA replication many factors can result in DNA replication stress. The DNA replication stress checkpoint prevents the accumulation of replication stress-induced DNA damage and the potential ensuing genome instability. A critical role for post-translational modifications, such as phosphorylation, in the replication stress checkpoint response has been well established. However, recent work has revealed an important role for transcription in the cellular response to DNA replication stress. In this review, we will provide an overview of current knowledge of the cellular response to DNA replication stress with a specific focus on the DNA replication stress checkpoint transcriptional response and its role in the prevention of replication stress-induced DNA damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
