Journal
GENES
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/genes8050138
Keywords
DNA methylation; epigenetics; cocaine; addiction
Categories
Funding
- National Institute of Drug Addiction (NIDA) [DA033684]
- Canadian Institute of Health Research Frederick Banting and Charles Best Doctoral Award
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Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research.
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