Journal
GENES
Volume 8, Issue 2, Pages -Publisher
MDPI AG
DOI: 10.3390/genes8020066
Keywords
p53 dynamics; cell fate decision; cell signaling network
Categories
Funding
- National Science Foundation of China [81372945]
- National Institutes of Health [R01ES023569]
Ask authors/readers for more resources
Cellular stress-induced temporal alterationsi.e., dynamicsare typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53-based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53-based cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available