Journal
GENES
Volume 8, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/genes8030089
Keywords
epigenetics; stroke; recovery
Categories
Funding
- National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health [RO1 NS075156, RO1 NS088656]
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While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.
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