Journal
GENES
Volume 8, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/genes8020057
Keywords
dNTP; DNA polymerase; genome instability; ribonucleotide reductase; replication fidelity; proofreading
Categories
Funding
- BBSRC [BB/K016598/1]
- Medical Research Council [MR/L016591/1]
- BBSRC [BB/K016598/1] Funding Source: UKRI
- MRC [MR/L016591/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K016598/1] Funding Source: researchfish
- Medical Research Council [MR/L016591/1] Funding Source: researchfish
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A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.
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