Journal
GENES
Volume 8, Issue 11, Pages -Publisher
MDPI AG
DOI: 10.3390/genes8110301
Keywords
RNA modification; pseudouridine synthase; dyskerin; non-coding RNA; gene expression control; cancer; inherited disorders
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research: AIRC) [IG-16962]
- Fondazione Umberto Veronesi
Ask authors/readers for more resources
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-generation sequencing techniques used in the detection of RNA modifications, pseudouridylation sites have been described in most eukaryotic RNA classes. In the present review, we will first consider the available information on the functional roles of pseudouridine(s) in different RNA species. We will then focus on how alterations in the pseudouridylation process may be connected with a series of human pathologies, including inherited disorders, cancer, diabetes, and viral infections. Finally, we will discuss how the availability of novel technical approaches are likely to increase the knowledge in this field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available