Journal
GENES
Volume 8, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/genes8020055
Keywords
telomere; telomere replication; G-quadruplex; T-loop; TERRA
Categories
Funding
- Association pour la Recherche contre le Cancer (Projet Fondation ARC)
- Agence Nationale de la Recherche (ANR-QuiescenceDNA)
- Ligue Nationale Contre le Cancer (LNCC)
- LNCC (Equipe labelisee)
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Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity.
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