Related references
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Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents
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Contribution of the S5-Pore-S6 Domain to the Gating Characteristics of the Cation Channels TRPM2 and TRPM8
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Four Ca2+ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
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JOURNAL OF GENERAL PHYSIOLOGY (2009)
Intracellular calcium activates TRPM2 and its alternative spliced isoforms
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TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells
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Genomic survey of candidate stress-response genes in the estuarine anemone Nematostella vectensis
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BIOLOGICAL BULLETIN (2008)
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)
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BRITISH JOURNAL OF PHARMACOLOGY (2008)
Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis
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ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site
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FASEB JOURNAL (2008)
Evolutionary determinants of divergent calcium selectivity of TRPM channels
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Role of the α-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP
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The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes
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JOURNAL OF GENERAL PHYSIOLOGY (2007)
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SCIENCE (2007)
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2
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Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes
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Metabolite of SIR2 reaction modulates TRPM2 ion channel
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TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
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Structural characterization of the histone variant macroH2A
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The macro domain is an ADP-ribose binding module
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EMBO JOURNAL (2005)
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1
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Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel
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NEURON (2004)
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
E Fonfria et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2
FJP Kühn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The crystal structure and mutational analysis of human NUDT9
BW Shen et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
NUDT9, a member of the nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase
AL Perraud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide -: A splice variant reveals a mode of activation independent of ADP-ribose
E Wehage et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
KP Schlingmann et al.
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Molecular basis for species-specific sensitivity to hot chili peppers
SE Jordt et al.
CELL (2002)
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death
Y Hara et al.
MOLECULAR CELL (2002)
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
AL Perraud et al.
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TRP-PLIK, a bifunctional protein with kinase and ion channel activities
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SCIENCE (2001)