Journal
FRONTIERS IN PHYSIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2017.00368
Keywords
enamel biomimetics; elastin-like proteins; fluorapatite; biomineralization model
Categories
Funding
- Life Science Initiative, QMUL
- European Research Council Starting Grant (STROFUNSCAFF)
- Marie Curie Career Integration Grant (BIOMORPH)
- EPSRC [EP/M022749/1]
- EPSRC [EP/L02263X/1, EP/M022749/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L02263X/1, EP/M022749/1] Funding Source: researchfish
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The process of enamel biomineralization is multi-step, complex and mediated by organic molecules. The lack of cells in mature enamel leaves it unable to regenerate and hence novel ways of growing enamel-like structures are currently being investigated. Recently, elastin-like protein (ELP) with the analog N-terminal sequence of statherin (STNA15-ELP) has been used to regenerate mineralized tissue. Here, the STNA15-ELP has been mineralized in constrained and unconstrained conditions in a fluoridated solution. We demonstrate that the control of STNA15-ELP delivery to the mineralizing solution can form layered ordered fluorapatite mineral, via a brushite precursor. We propose that the use of a constrained STNA15-ELP system can lead to the development of novel, bioinspired enamel therapeutics.
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