Neurosensory and Cognitive Modifications in Europe's Toughest RandoRaid Competition: the Transpyrenea Extreme Study

Introduction: Given the wide proliferation of ultra-long endurance races, it is important to understand the physiological response of the athletes to improve their safety. We evaluated the cognitive and neurosensory effects on ultra-endurance athletes during the Transpyrenea(866 Km, 65,000m positive slope), held on the French Pyrenees. Materials and Methods: 40 athletes were enrolled (age 43.8 +/- 8.8 years; 36 males). Olfactory and cognitive tests were performed before the race (T0, n = 40), at 166 kms (T1, n = 28), at 418 kms (T2, n = 20), and after the race (T3, 866 kms, n = 13). The effect of dehydration and sleep deprivation on cognitive features were also studied. Results: Olfactory function decreased during the race (T0: 24.9 +/- 4.3 vs. T3: 22.8 +/- 3.5, z = - 2.678, p = 0.007), language fluency increased (T0: 10.8 +/- 2.9; T1: 11.4 +/- 2.7; T2: 12.9 +/- 2.8; T3: 12.9 +/- 3.0; $ 2 = 11.132, p = 0.011 for combined samples), whereas the Trail Making Test did not show any changes between pre-and post-race (T0 vs. T3 p = 0.697 for TMT- A, p = 0.977 for TMT- B). The mean aggregate sleeping time was 9.3 +/- 5.4 h at T1, 22.4 +/- 10.0 h at T2, 29.5 +/- 20.5 h at T3, with a correlation with olfactory function (r = 0.644, p = 0.018), while Total Body Water (TBW) was not correlated with olfactory or cognitive scores. Conclusion: Physical activity and sleep restriction in ultra-endurance could transiently affect olfactory function, while verbal fluency improved, demonstrating a dissimilar mechanism of activation/deactivation in different cortical areas. Body water loss was uncorrelated to cognition. Further studies should clarify whether cognitive and sensory deficits occur even in absence of sleep restriction.