Journal
FRONTIERS IN PHARMACOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2017.00855
Keywords
fibrosis; drug; target; pathological mechanism; pharmacology
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Funding
- National Natural Science Foundation of China [31200986, 41530105]
- Natural Science Foundation
- Shanghai Committee of Science and Technology [16ZR1449800]
- Peter and Tommy Fund, Inc., Buffalo, NY
- University at Buffalo Community of Excellence in Genome, Environment and Microbiome (GEM)
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Fibrosis contributes to the development of many diseases and many target molecules are involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to specific diseases or organs. However, accumulating evidence demonstrates great similarities among fibroproliferative diseases, and more and more drugs are proved to be effective anti-fibrotic therapies across different diseases and organs. Here we comprehensively review the current knowledge on the pathological mechanisms of fibrosis, and divide factors mediating fibrosis progression into extracellular and intracellular groups. Furthermore, we systematically summarize both single and multiple component drugs that target fibrosis. Future directions of fibrosis drug discovery are also proposed.
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