Journal
FRONTIERS IN PHARMACOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2017.00039
Keywords
Alzheimer'sdisease; ICS II; beta-amyloid; neuroinflammation; apoptosis
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Funding
- Science and Technology Innovation Talent Team of Guizhou Province [20154023]
- Outstanding Youth Science and Technology Talent Capital of Guizhou Province [201326]
- Guizhou Provincial Health and Family Planning Commission of Science and Technology Foundation [gzwjkj2014-1-069]
- Zunyi Medical University [LH-[2015]7533, [2016]29]
- mutual fund combined Guizhou Province
- Science and Technology Joint Fund of combined Zunyi Science and Technology Bureau
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Beta-amyloid (A beta) deposition, associated neuronal apoptosis and neuroinflammation are considered as the important factors which lead to cognitive deficits in Alzheimer's disease (AD). Icariside II (ICS II), an active flavonoid compound derived from Epimedium brevicornum Maxim, has been extensively used to treat erectile dysfunction, osteoporosis and dementia in traditional Chinese medicine. Recently, ICS II attracts great interest due to its broad-spectrum anti-cancer property. ICS II shows an anti-inflammatory potential both in cancer treatment and cerebral ischemia-reperfusion. It is not yet clear whether the anti-inflammatory effect of ICS II could delay progression of AD. Therefore, the current study aimed to investigate the effects of ICS II on the behavioral deficits, A beta levels, neuroinflammatory responses and apoptosis in A beta(25-35)-treated rats. We found that bilateral hippocampal injection of A beta(25-35) induced cognitive impairment, neuronal damage, along with increase of A beta, inflammation and apoptosis in hippocampus of rats. However, treatment with ICS II 20 mg/kg could improve the cognitive deficits, ameliorate neuronal death, and reduce the levels of A beta in the hippocampus. Furthermore, ICS II could suppress microglial and astrocytic activation, inhibit expression of IL-1 beta, TNF-alpha, COX-2, and iNOS mRNA and protein, and attenuate the A beta induced Bax/Bcl-2 ratio elevation and caspase-3 activation. In conclusion, these results showed that ICS II could reverse A beta-induced cognitive deficits, possibly via the inhibition of neuroinflammation and apoptosis, which suggested a potential protective effect of ICS II on AD.
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