Journal
NATURAL PRODUCTS AND BIOPROSPECTING
Volume 6, Issue 5, Pages 233-237Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13659-016-0107-5
Keywords
Heracleum stenopterum; Peucedanum praeruptorum; Clausena lansium; Murraya paniculata; Prenylated coumarin; Cytotoxicity
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Funding
- Large-scale Compound Library project of National Development and Reform Commission of China
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Four hitherto unknown prenylated coumarins, namely 6 ''-O-beta-D-apiofuranosylapterin (1), 4'-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC50 values ranging from 15.9 to 23.2 mu M. [GRAPHICS] .
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