Journal
FRONTIERS IN PHARMACOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2017.00411
Keywords
tumor metabolism; proton dynamics; tumor microenvironment; cancer imaging; cancer therapy
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Funding
- EORTC
- Belgian Televie
- EACR
- Belgian Fonds National de la Recherche Scientifique (F.R.S.-FNRS)
- University of Louvain (UCL) Health Sector
- Seahorse Biosciences (Agilent Technologies)
- Ibidi/Proxylab
- Essen Bioscience
- Cellomet
- Labconsult (Don Whitley Scientific)
- Promega
- VWR
- BioTechne
- Merck and BD Biosciences
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Cancers are metabolic entities wherein cancer cells adapt their metabolism to their oncogenic agenda and microenvironmental influences. Metabolically different cancer cell subpopulations collaborate to optimize nutrient delivery with respect to immediate bioenergetic and biosynthetic needs. They can also metabolically exploit host cells. These metabolic networks are directly linked with cancer progression, treatment resistance and relapse. Conversely, metabolic alterations in cancer are exploited for anticancer therapy, imaging and personalized medicine. These topics were addressed at the 3rd annual meeting of the International Society of Cancer Metabolism (ISCaM) in Brussels, Belgium, on 26-29 October 2016.
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