Journal
FRONTIERS IN NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2017.00106
Keywords
B-1(+) map; T-1 map; error propagation; uncertainty; precision; variable flip angle
Categories
Funding
- Wellcome Trust [091593/Z/10/Z]
- Swiss National Science Foundation [31003A_166118]
- Swiss National Science Foundation (SNF) [31003A_166118] Funding Source: Swiss National Science Foundation (SNF)
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In magnetic resonance imaging, precise measurements of longitudinal relaxation time (T-1 ) is crucial to acquire useful information that is applicable to numerous clinical and neuroscience applications. In this work, we investigated the precision of T-1 relaxation time as measured using the variable flip angle method with emphasis on the noise propagated from radiofrequency transmit field (B-1(+)) measurements. The analytical solution for T-1 precision was derived by standard error propagation methods incorporating the noise from the three input sources: two spoiled gradient echo (SPGR) images and a B-1(+) map. Repeated in vivo experiments were performed to estimate the total variance in T-1 maps and we compared these experimentally obtained values with the theoretical predictions to validate the established theoretical framework. Both the analytical and experimental results showed that variance in the B-1(+) map propagated comparable noise levels into the T-1 maps as either of the two SPGR images. Improving precision of the BT measurements significantly reduced the variance in the estimated T-1 map. The variance estimated from the repeatedly measured in vivo T-1 maps agreed well with the theoretically-calculated variance in T-1 estimates, thus validating the analytical framework for realistic in vivo experiments. We concluded that for T-1 mapping experiments, the error propagated from the B-1(+) map must be considered. Optimizing the SPGR signals while neglecting to improve the precision of the B-1(+) map may result in grossly overestimating the precision of the estimated T-1 values.
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