Journal
FRONTIERS IN NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2016.00617
Keywords
neuroimaging; non-human primate; macaque; computational atlases; white matter pathways; magnetic resonance imaging; diffusion tensor imaging; automatic segmentation
Categories
Funding
- NIH grant: UNC Intellectual and Developmental Disabilities Research Center [P30 HD03110, MH091645]
- NIH grant: Office of Research Infrastructure Programs/OD grant [OD11132]
- [MH086633]
- [P50 MH064065]
- [MH070890]
- [HD053000]
- [U54 EB005149-01]
- [P50 MH078105]
- [MH078105-S1]
- [HD055255]
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Computational anatomical atlases have shown to be of immense value in neuroimaging as they provide age appropriate reference spaces alongside ancillary anatomical information for automated analysis such as subcortical structural definitions, cortical parcellations or white fiber tract regions. Standard workflows in neuroimaging necessitate such atlases to be appropriately selected for the subject population of interest. This is especially of importance in early postnatal brain development, where rapid changes in brain shape and appearance render neuroimaging workflows sensitive to the appropriate atlas choice. We present here a set of novel computation atlases for structural MRI and Diffusion Tensor Imaging as crucial resource for the analysis of MRI data from non-human primate rhesus monkey (Macaca mulatta) data in early postnatal brain development. Forty socially-housed infant macaques were scanned longitudinally at ages 2 weeks, 3, 6, and 12 months in order to create cross-sectional structural and DTI atlases via unbiased atlas building at each of these ages. Probabilistic spatial prior definitions for the major tissue classes were trained on each atlas with expert manual segmentations. In this article we present the development and use of these atlases with publicly available tools, as well as the atlases themselves, which are publicly disseminated to the scientific community.
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