Journal
TOMOGRAPHY
Volume 2, Issue 4, Pages 260-266Publisher
GRAPHO PUBLICATIONS
DOI: 10.18383/j.tom.2016.00142
Keywords
quantitative MR; breast cancer; pool size ratio; test-retest
Funding
- National Institutes of Health [NCATS UL1 TR000445, NCI U01CA174706, NCI 1U01CA142565, NCI 1P50 098131, NIH EB013659, NIH P30 CA68485, CPRIT RR160005]
- Kleberg Foundation
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Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique's reproducibility in healthy breast tissue must be established. Thus, this study aims to establish the reproducibility of the measurement of the macromolecular-to-free water proton pool size ratio (PSR) in healthy fibroglandular (FG) breast tissue. Thirteen women with no history of breast disease were scanned twice within a single scanning session, with repositioning between scans. Eleven women had appreciable FG tissue for test-retest measurements. Mean PSR values for the FG tissue ranged from 9.5% to 16.7%. The absolute value of the difference between 2 mean PSR measurements for each volunteer ranged from 0.1% to 2.1%. The 95% confidence interval for the mean difference was +/- 0.75%, and the repeatability value was 2.39%. These results indicate that the expected measurement variability would be +/- 0.75% for a cohort of a similar size and would be +/- 2.39% for an individual, suggesting that future studies of change in PSR in patients with breast cancer are feasible.
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