Journal
NATURAL PRODUCTS AND BIOPROSPECTING
Volume 6, Issue 3, Pages 155-160Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13659-016-0094-6
Keywords
Endophytic fungi; Pestalotiopsis sp. M-23; Leucosceptrum canum; Drimane sesquiterpenoids; Antibacterial activity
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Funding
- National Natural Science Foundation of China [31525005, U1202263, 31570362]
- Youth Innovation Promotion association of Chinese Academy of Sciences
- Western Light'' Program of Chinese Academy of Sciences
- Hundred Talents Program'' of the Chinese Academy of Sciences
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Three new drimane sesquiterpenoids (1-3) together with the known 2a-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae). Their structures were determined by comprehensive 1D and 2D NMR, and MS analyses. The metabolites were evaluated for their antibacterial activities, and compound 3 showed weak inhibitory activity against Bacillus subtilis.
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