Journal
CLINICAL INTERVENTIONS IN AGING
Volume 12, Issue -, Pages 1811-1817Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S142483
Keywords
COPD; metformin; melatonin; statins; vitamin D; testosterone
Categories
Ask authors/readers for more resources
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available