Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 124, Issue 4, Pages 300-305Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2017.1396349
Keywords
Type 2 diabetes; obesity; circulating microRNA; miR-21; miR-126; miR-146a
Funding
- Tehran University of Medical Sciences [96-01-30-33989]
- Diabetes Research Center, Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences [1393-01-97-1773]
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Background: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects. Methods: Forty two healthy and 45 T2D subjects participated in this study. Serum miR-21, miR-126, and miR-146a levels were measured using real-time PCR. Results: There was no significant difference in the serum level of miR-21, miR-126, and miR-146a between the diabetic and non-diabetic groups. The level of miR-21 in obese non-diabetic and diabetic subjects was significantly lower than lean subjects. Correlation analyses in non-diabetic and diabetic groups revealed a significant negative correlation between the amount of miR-21 and body mass index, waist circumference, insulin, and HOMA-IR levels. Conclusions: A reduced level of miR-21 might associate with obesity and its related metabolic traits such as hyperinsulinaemia.
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