Journal
ANNALS OF INTENSIVE CARE
Volume 7, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1186/s13613-017-0337-7
Keywords
Platelets; Sepsis; Inflammation; Intensive care
Categories
Funding
- European Community
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Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.
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