Journal
ACS PHOTONICS
Volume 5, Issue 2, Pages 471-479Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsphotonics.7b00983
Keywords
silicon; nanowires; biosensor; photoluminescence; C-reactive protein
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Funding
- PON SISTEMA (MIUR) Project
- TECLA [PON_00214_1]
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We demonstrate the realization of the first label-free optical biosensor based on the room temperature luminescence of silicon nanowires (NWs) tested for the selective detection of C-reactive protein in human serum. High aspect ratio Si NW arrays used as sensing interface, are synthesized by a fast, low cost and Si industrially compatible approach. Si NW optical biosensors are fast and offer a broad concentration dynamic range that can be tuned according to different applications. Moreover, the platform is endowed with a high selectivity toward the target analyte and a sensitivity down to the fM limit of detection, opening the route toward noninvasive analysis in biofluids such as saliva.
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