Journal
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
Volume 6, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/wdev.270
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Funding
- CIHR [137092]
- NIH [AR064195]
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Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. (C) 2017 Wiley Periodicals, Inc.
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