Journal
HEPATIC ONCOLOGY
Volume 3, Issue 3, Pages 193-200Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/hep-2016-0005
Keywords
hepatocellular carcinoma; lyso-thermosensitive liposomal doxorubicin; radiofrequency ablation
Categories
Funding
- Celsion Corporation
Ask authors/readers for more resources
When heated during a radiofrequency ablation (RFA) procedure to >= 40 degrees C, lyso-thermosensitive liposomal doxorubicin (LTLD) produces high drug concentration in the surrounding margins of the ablation zone. The hypothesis that the RFA + LTLD combination can effectively treat hepatocellular carcinoma was investigated in the HEAT study: adding LTLD did not improve the efficacy of normal practice RFA. However, among the 285 patients with a solitary lesion who received at least 45-min RFA dwell time, the hazard ratio for overall survival was 0.63 (95% CI: 0.41-0.96; p = 0.04). The OPTIMA study is currently ongoing to test the hypothesis that adding LTLD to a standardized RFA lasting >= 45 min increases survival compared with standardized RFA alone.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available