3.8 Article

Membrane Glycolipids Content Variety in Gastrointestinal Tumors and Transplantable Hepatomas in Mice

Journal

MEDICAL SCIENCE MONITOR BASIC RESEARCH
Volume 22, Issue -, Pages 87-90

Publisher

INT SCIENTIFIC LITERATURE, INC
DOI: 10.12659/MSMBR.899635

Keywords

G(M3) Ganglioside; Intestinal Neoplasms; Membrane Glycoproteins; Stomach Neoplasms

Funding

  1. Anhui Province Key Laboratory of Active Biological Macromolecules [1306C083008]
  2. National Natural Science Foundation of China [30900243]

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Background: The aim of this study was to investigate the variety of plasma contents of membrane glycolipids in 65 gastrointestinal tumors and 31 transplant hepatomas in mice. Material/Methods: The experimental model was a transplantable murine hepatoma. Experimental mice were divided into 3 groups. Results: The LSA and TSA content in the 2 groups were significantly difference (p<0.01), and were significantly lower in the therapeutic group than in the control group (p<0.01). Conclusions: These results indicate that membrane glycolipids index LSA and TSA are sensitive markers in gastrointestinal tumors. In the transplanted hepatomas in mice, they may be considered as ancillary indicators for judging the therapeutic effect of hepatoma.

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