Journal
DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE
Volume 6, Issue -, Pages 111-118Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DNND.S87323
Keywords
respiratory failure; hereditary myopathy; amyotrophic lateral sclerosis; myopathy; noninvasive ventilation
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Neuromuscular ventilatory weakness can be difficult to recognize because the symptoms can be nocturnal, nonspecific, or attributed to other conditions. The presence of respiratory muscle weakness suggests a number of possible heterogeneous conditions, including neurodegenerative, autoimmune, and genetic neuromuscular diseases. In some conditions, disease-modifying management exists, but in the absence of such intervention, supportive respiratory therapy can improve quality of life and survival. In this review, we discuss the differential diagnosis and diagnostic approach to chronic neuromuscular respiratory weakness. We also review the clinical assessment and management of respiratory failure in these conditions.
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