Journal
JOURNAL OF PEDIATRIC GENETICS
Volume 5, Issue 2, Pages 78-83Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1579760
Keywords
familial adenomatous polyposis; Turcot syndrome; Gardner syndrome
Categories
Ask authors/readers for more resources
Familial adenomatous polyposis (FAP), caused by a germline mutation in the adenomatous polyposis coli (APC) gene on chromosome 5q21, is an autosomal dominant disorder characterized by hundreds to thousands of adenomas throughout the gastrointestinal tract. A variety of extraintestinalmanifestations, including thyroid, soft tissue, and brain tumors, may also be present. These patients inevitably develop colorectal carcinoma by the fourth decade of life. In this review, the pathology, epidemiology, and genetic features of FAP are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available