Journal
STEM CELL REVIEWS AND REPORTS
Volume 13, Issue 3, Pages 407-417Publisher
SPRINGER
DOI: 10.1007/s12015-017-9741-5
Keywords
Microfluidics; Bioprinting; Bone tissue models; Personalized medicine
Funding
- Italian Ministry of Health
- Office of the Assistant Secretary of Defense for Health Affairs through the Breast Cancer Research Program [W81XWH-15-1-0092]
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The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.
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