Journal
PATHOGENS AND DISEASE
Volume 75, Issue 5, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftx046
Keywords
pattern recognition receptors; galectins; beta-galactoside; carbohydrate recognition domain: glycans; structure; function; proto-type; chimera; tandem repeat
Categories
Funding
- National Institutes of Health [R01GM070589, 5T32AI095190-03]
- National Science Foundation [IOS 1050518, IOB-0618409, IOS-0822257]
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Carbohydrate structures on the cell surface encode complex information that through specific recognition by carbohydrate-binding proteins (lectins) modulates interactions between cells, cells and the extracellular matrix, or mediates recognition of potential microbial pathogens. Galectins are a family of beta-galactoside-binding lectins, which are evolutionary conserved and have been identified in most organisms, from fungi to invertebrates and vertebrates, including mammals. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of endogenous carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their roles in tissue repair and regulation of immune homeostasis. More recently, evidence has accumulated to support the notion that galectins can also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity, thus establishing a new paradigm. Furthermore, some parasites 'subvert' the recognition roles of the vector/host galectins for successful attachment or invasion. These recent findings have revealed a striking functional diversification in this structurally conserved lectin family.
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