Journal
PATHOGENS AND DISEASE
Volume 75, Issue 9, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftx115
Keywords
Wolbachia; lymphatic filariasis; nematode; endosymbiont; genomics; Wuchereria bancrofti
Categories
Funding
- National Institutes of Health [AI103263]
- National Institute of Allergy and Infectious Diseases [U19AI110820]
- T32 Postdoctoral Fellowship in Geographic Medicine and Infectious Disease [AI007024]
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The draft genome assembly of the Wolbachia endosymbiont of Wuchereria bancrofti (wWb) consists of 1060 850 bp in 100 contigs and contains 961 ORFs, with a single copy of the 5S rRNA, 16S rRNA and 23S rRNA and each of the 34 tRNA genes. Phylogenetic core genome analyses show wWb to cluster with other strains in supergroup D of the Wolbachia phylogeny, while being most closely related to the Wolbachia endosymbiont of Brugia malayi strain TRS (wBm). The wWb and wBm genomes share 779 orthologous clusters with wWb having 101 unclustered genes and wBm having 23 unclustered genes. The higher number of unclustered genes in the wWb genome likely reflects the fragmentation of the draft genome.
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