Journal
NUCLEUS
Volume 8, Issue 6, Pages 613-624Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2017.1358329
Keywords
LINC; meiosis; recombination; synapsis
Categories
Funding
- National Science Foundation [1515551]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1515551] Funding Source: National Science Foundation
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Meiosis is a specialized cellular division occurring in organisms capable of sexual reproduction that leads to the formation of gametes containing half of the original chromosome number. During the earliest stage of meiosis, prophase I, pairing of homologous chromosomes is achieved in preparation for their proper distribution in the coming divisions. An important question is how do homologous chromosomes find each other and establish pairing interactions. Early studies demonstrated that chromosomes are dynamic in nature and move during this early stage of meiosis. More recently, there have been several studies across different models showing the conserved nature and importance of this chromosome movement, as well as the key components involved in chromosome movement. This review will cover these major findings and also introduce unexamined areas of regulation in meiotic prophase I chromosome movement.
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