Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 23, Issue 2, Pages 300-303Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458516670734
Keywords
Natalizumab; JC virus; progressive multifocal leukoencephalopathy; multiple sclerosis; transmission
Categories
Funding
- Swiss National Foundation [320030_138411]
- Swiss Multiple Sclerosis Society
- Swiss National Science Foundation (SNF) [320030_138411] Funding Source: Swiss National Science Foundation (SNF)
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Background: Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML). Objective: We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1. Conclusion: The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.
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