Journal
MICROMACHINES
Volume 8, Issue 11, Pages -Publisher
MDPI AG
DOI: 10.3390/mi8110329
Keywords
optofluidics; microfluidics; diffusion; convection; mixing; refractive index; label-free
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Funding
- Danish Council for Strategic Research, DSF [10-092322]
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Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).
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