Journal
MEDICAL SCIENCE MONITOR
Volume 23, Issue -, Pages 315-324Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.902752
Keywords
Chemoradiotherapy; Neutrophils; Prognosis
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Funding
- Natural Scientific Foundation of China [81402429]
- Natural Science Foundation of Zhejiang [LY14H60009]
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Background: Increasing evidence suggests that cancer-associated inflammation is associated with poorer outcomes. The neutrophil- to-lymphocyte ratio (NLR), considered as a systemic inflammation marker, is thought to predict prognoses in colorectal cancer. In this study, we explored the association between the NLR and prognoses following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). Material/Methods: From February 2002 to December 2012, a group of 202 patients diagnosed with LARC and receiving neoadjuvant CRT followed by radical surgery was included in our retrospective study. The associations between the pre-CRT NLR and clinicopathological characteristics, as well as the predictive value of pre-CRT NLR against survival outcomes, were analyzed. Results: The average NLR was 2.7 +/- 1.5 (median 2.4, range 0.6-12.8). There were 63 (31.2%) patients with NLR >= 3.0, and 139 (68.8%) patients with NLR < 3.0. Correlation analyses showed that no clinicopathological characteristics except age were associated with NLR. We did not find an association between NLR and survival outcomes. In multivariate Cox model analyses, the R1/R2 resection, lymph node ratio >= 0.1, and perineural/lymphovascular invasion were independently associated with worse disease-free survival and overall survival. Conclusions: In our cohort, the NLR did not correlate with survival outcomes in LARC patients undergoing neoadjuvant CRT. The prognostic value of NLR should be validated in large-scale prospective studies.
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