Journal
CURRENT DIABETES REVIEWS
Volume 12, Issue 4, Pages 331-358Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573399812666150918150608
Keywords
Glucagon-like peptide-1; oxidative stress; diabetes; diabetic complications
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Funding
- Lifepharm Centre for in vivo pharmacology at University of Copenhagen
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Glucagon-like peptide-1 (GLP-1) has shown to influence the oxidative stress status in a number of in vitro, in vivo and clinical studies. Well-known effects of GLP-1 including better glycemic control, decreased food intake, increased insulin release and increased insulin sensitivity may indirectly contribute to this phenomenon, but glucose-independent effects on ROS level, production and antioxidant capacity have been suggested to also play a role. The potential 'antioxidant' activity of GLP-1 along with other proposed glucose-independent modes of action related to ameliorating redox imbalance remains a controversial topic but could hold a therapeutic potential against micro-and macrovascular diabetic complications. This review discusses the presently available knowledge from experimental and clinical studies on the effects of GLP-1 on oxidative stress in diabetes and diabetes-related complications.
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