Journal
THERAPEUTIC DELIVERY
Volume 7, Issue 12, Pages 795-808Publisher
FUTURE SCI LTD
DOI: 10.4155/tde-2016-0050
Keywords
macrophage; nanoemulsion; perfluorocarbon; perfluoropolyether; resveratrol; theranostic
Categories
Funding
- National Institute on Drug Abuse [R21DA03962102]
- National Institute of Biomedical Imaging and Bioengineering [R21EB02310-01]
- Duquesne University Research Funds
- Faculty Development Funds, Duquesne University
- Undergraduate Research Program at Duquesne University - National Science Foundation, Major Research Instrumentation [CHE-1126465]
- NIH [1 R25 DA032519-01]
Ask authors/readers for more resources
Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release. Conclusion: PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available