Journal
ENDOCRINOLOGY AND METABOLISM
Volume 31, Issue 4, Pages 519-524Publisher
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2016.31.4.519
Keywords
Hypothalamus; Brain stem; Energy metabolism; Obesity
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning [2013M3C7A1056024, 2015M3A9E7029172]
- National Research Foundation of Korea [2015M3A9E7029177] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the periphery via the autonomic nervous system. A specialized neuronal network coordinates energy intake behavior and the metabolic processes affecting energy expenditure. Here, we briefly review neuronal mechanisms by which our body maintains energy balance.
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