Journal
TRANSCRIPTION-AUSTIN
Volume 7, Issue 3, Pages 91-95Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2016.1182240
Keywords
chromatin; DNA repair; DNA supercoiling; elongation; intermediates; intranucleosomal DNA loops; mechanism; nucleosome; RNA polymerase II; single strand DNA breaks; structure; transcription
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Funding
- NIH [GM58650]
- Russian Science Foundation (RSF) [14-24-00031]
- Intramural Research Program of the National Institutes of Health (NICHD)
- Russian Science Foundation [14-24-00031] Funding Source: Russian Science Foundation
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RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.
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